“This is the first report that showed the efficacy of methionine restriction to reverse old-age-induced obesity.” Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. A recent study published in the journal Aging found that restricting the a
Mouse body weight increases with age, but obesity in older mice was reversed with a methionine-deficient diet or treatment with methionine-restricting E. coli JM109-rMETase. Both methods significantly lowered methionine levels, with the diet being more effective, and did not decrease lean muscle mass. Although humans find it hard to restrict methionine by diet alone, oral methioninase and engineered E.
Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. A recent study published in the journalmethionine affects fat metabolism and could help prevent obesity. In the study, they observed that C57BL/6 mice doubled their body weight from 4 to 48 weeks, becoming obese in the process.
“In the present study, we tested a low-methionine diet to reverse old-age-induced obesity. […] E. coli JM109-rMETase was also tested in the present study to reverse old-age-induced obesity.”Fifteen C57BL/6 male mice aged 12–18 months with old-age-induced obesity were divided into three groups. Group 1 was given a normal diet supplemented with non-recombinant E. coli JM109 cells orally by gavage twice daily; Group 2 was given a normal diet supplemented with recombinant E.
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