A large-scale clinical trial discovered that two diabetes drugs outperform others. Researchers from the University of Minnesota Medical School contributed to the finding that insulin glargine and liraglutide worked best in a large clinical trial that directly evaluated four drugs frequently used t
When compared to sitagliptin or glimepiride, the study’s participants who were taking metformin together with liraglutide or insulin glargine were able to reach and maintain their target blood levels for the longest periods of time.Researchers from the
Medical School contributed to the finding that insulin glargine and liraglutide worked best in a large clinical trial that directly evaluated four drugs frequently used to treat type 2 diabetes. The findings were recently published in“The GRADE study is the first to compare the efficacy of four drugs commonly used to treat type 2 diabetes when added to metformin in people with short-duration diabetes.
When compared to sitagliptin or glimepiride, patients receiving metformin plus liraglutide or insulin glargine reached and maintained their target blood levels for the longest period. When compared to sitagliptin, which was the least effective in sustaining target levels, this translated into nearly six months of extra time with blood glucose levels in the target range. Age, sex, race, or ethnicity had no impact on how well a treatment worked.
Launched in 2013, the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study was conducted at centers across the country, including the University of Minnesota. It was designed to compare four major medications approved by the Food and Drug Administration at the time GRADE started to treat diabetes in combination with metformin.
References: “Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes” by David M. Nathan, M.D., John M. Lachin, Sc.D., Ashok Balasubramanyam, M.D., Henry B. Burch, M.D., John B. Buse, M.D., Nicole M. Butera, Ph.D., Robert M. Cohen, M.D., Jill P. Crandall, M.D., Steven E. Kahn, M.B., Ch.B., Heidi Krause-Steinrauf, M.S., Mary E. Larkin, R.N., Neda Rasouli, M.D., Margaret Tiktin, D.N.P., Deborah J. Wexler, M.D. and Naji Younes, Ph.D.
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