A study has discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.
A study led by researchers at Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.
The team's discoveries were made possible through the development of an innovative computational tool in the lab of the study's other senior author, Ashley Laughney, PhD, an assistant professor of physiology and biophysics and member of the Institute for Computational Biomedicine at Weill Cornell Medicine. Dubbed ContactTracing, the approach predicts cell-to-cell interactions and also examines how different cells respond to stimuli in growing tumors.
"We knew that chromosomal instability is an important driver of cancer's ability to spread, otherwise known as metastasis," Dr. Bakhoum says."What we discovered here is that the immune system plays a central role in this process."A previous collaboration between researchers at MSK and Weill Cornell Medicine, which was also published in, showed the complex chain of events triggered by chromosomal instability leads to changes in cells that drive cancer metastasis.
For example, the researchers treated a simple type of cell, known as a fibroblast, with a STING agonist -- the foundation for the drugs developed for human patients -- and observed a strong initial immune response. The method is based on the simple premise that in a given tumor, there is inherent biological diversity -- not every cancer cell is going to secrete the same binding molecule, or ligand. And not every immune cell is going to express the right receptor for that ligand, Dr. Laughney explains.
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