A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer (ccRCC) patients according to new research published in the May issue of The Journal of Nuclear Medicine.
May 7 2024Society of Nuclear Medicine and Molecular Imaging A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer patients according to new research published in the May issue of The Journal of Nuclear Medicine . The results of the study suggest that the agent 68Ga-DPI-4452 is superior to standard CT imaging in the context of ccRCC.
The carbonic anhydrase IX encoding gene is overexpressed in more than 90 percent of ccRCC cases and is restricted to gastrointestinal tissue, presenting both diagnostic and therapeutic opportunities. In this study, we aim to assess the safety, tolerability, and imaging characteristics of the CAIX-targeting imaging agent 68Ga-DPI-4452 ."
This ongoing first-in-human GaLuCi study included three patients with histologically confirmed unresectable locally advanced or metastatic ccRCC who had received at least two lines of treatment in a metastatic setting. Patients received 68Ga-DPI-4452 and underwent whole-body PET/CT at 15 minutes, and one, two, and four hours after administration. Images from these three initial patients were analyzed, and pharmacokinetics and safety data were assessed.
Related Stories"68Ga-DPI-4452 PET/CT revealed an exceptionally high tumor-to-background ratio, with background tissues nearly invisible with the exception of gastro-intestinal uptake. One-hour after administration was deemed the optimal time point for lesion assessment, which is substantially shorter than the three to seven days needed in previous PET imaging studies using antibody approaches," said Hofman.
Cell Imaging Renal Cell Carcinoma Cancer CT Medicine Molecular Imaging Nuclear Medicine Research Surgery Tumor
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