Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain's aging process.
Rare and powerful
Cao studies how tissues and organs maintain stable populations of cells—a hallmark of health—so he and his team wanted to investigate how different cellular populations develop, and whether these varied neuronal cells decline in the same way or forge different paths. Tracking their cellular lifespans from birth to maturity would reveal not just differences, but also when they appeared.
This innovative technique allowed the researchers to analyze tens of thousands of gene expressions and the chromatin landscapes of these newborn cells as they grew into families of cell types with different molecular functions.across the entire brain in a single experiment, which wasn't possible using conventional approaches," Cao says."Those only capture static information—the current molecular state of a cell at a single moment.
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