Researchers at Karolinska Institute have developed a novel method using DNA nanoballs to detect pathogens, aiming to simplify nucleic acid testing and revolutionize pathogen detection. The study's results, published in Science Advances, could pave the way for a straightforward electronic-based test capable of identifying various nucleic acids in diverse scenarios quickly and cheaply.
Microfluidic chip for impedance-based detection of DNA nanoballs. A photograph of the 3-inch fused silica wafer with six microfluidic devices. Microscopic image of the channel with the integrated gold electrodes. Principle of detection of DNA nanoballs. The passing of a DNA nanoball through the integrated gold electrodes produces a spike signature in the impedance response of the system. This impedance response is recorded as a single DNA nanoball.
"The methodology involves combining Molecular Biology and electronics to yield a pioneering detection tool," says Vicent Pelechano. "Fast and accurate detection of genetic material is key for diagnosis, especially so in response to the emergence of novel pathogens," says Vicent Pelechano. Formation of DNA nanoball using six target-specific LAMP oligos and two compaction oligos. Fluorescence image of DNA nanoballs. Scale bar, 10 μm. Fluorescent image of 1 μM MyOne Dynabeads as size reference. Scale bar, 10 μm. Passive flow of DNA nanoballs in a microfluidic chip made of PDMS on a glass substrate integrated with gold electrodes. The passage of DNA nanoballs through the gold electrodes occludes the current path and disturbs the electric field formed between the gold electrodes.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
New zinc-air battery shows high power density, ultra-long stabilityAustralia-based researchers have redesigned zinc-air batteries by using a combination of new materials.
続きを読む »
New Report: Texas Among Top 5 States for New Business GrowthA new report shows record-breaking business growth nationwide and Texas, with its booming population growth, is among the states leading the pack.
続きを読む »
PrintWatch: Justice Society of America & New Golden Age Get New PrintsDC Comics' New Golden Age line expands with launches of Wesley Dodds: The Sandman, Jay Garrick: The Flash, and Alan Scott: Green Lantern
続きを読む »
Netflix new releases: 7 brand new titles you don't want to miss next weekA closer look at seven of the biggest and best new Netflix releases coming to the streaming service next week, including a pair of HBO series.
続きを読む »
New iPhone 15, iPhone 15 Pro Exclusive Details All-New Apple UpgradesThe last secrets of Apple's iPhone 15 and iPhone 15 Pro release have been revealed...
続きを読む »
Narendra Modi’s New New DelhiA multibillion-dollar revamp of India’s capital complex reflects the Prime Minister’s vision for the country’s future—and what he wants to erase from its past.
続きを読む »