A new lab assay developed by researchers at Fred Hutch Cancer Center could make diagnosis and treatment of small-cell lung cancer and non-small cell lung cancer easier.
Apr 10 2024Fred Hutchinson Cancer Center
"There is a deep need for blood-based assays that define subtypes in SCLC," said Fred Hutch SCLC researcher David MacPherson, PhD, who co-led the work with Fred Hutch computational biologist Gavin Ha, PhD. "This new method is a step towards assays that would allow us to test and monitor disease, detect when it transforms into a different lung cancer type, and identify potential treatment targets even when standard biopsies aren't an option.
To build the new assay, the research team developed a targeted strategy analyzing pre-clinical mouse models using human tissue in which cell-free tumor DNA was easier to sift out from DNA released by healthy cells. They found that the assay performed well when predicting whether DNA had come from an NSCLC or SCLC tumor, suggesting that their approach has potential for detecting when a patient's tumor transforms from NSCLC to SCLC.
Cancer Cell Lung Cancer Small Cell Lung Cancer Assay Blood DNA Non-Small Cell Lung Cancer Research Tumor
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