Science, Space and Technology News 2023
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Almost everyone experiences hearing loss at some point in their lives: Loud noises or simple aging gradually cause the auditory sensory cells and their synapses in the inner ear to degenerate and die off. The only treatment option is a hearing aid or, in extreme cases, a cochlear implant. Fluorescence microscopic image of a murine cochlea: the hair cells are marked in green, the cell skeleton in red, and the cell nuclei with genetic material in blue. Credit: Maurizio Cortada, University of Basel, Department of Biomedicine
When the researchers removed a central gene of this signaling pathway in the hair cells of the inner ear of mice, the animals gradually lost their hearing. By the age of twelve weeks, they were completely deaf, the authors report in the study.Closer examination indicated that the sensory hair cells in the inner ear lost their sensors without the mTORC2 signaling pathway: hair cells have protuberances similar to tiny hairs that are important for transducing sound into nerve signals.
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