Scientists have reversed diet-induced disease in obese mice by administering medication directly to the liver via a nanogel carrier, reducing the risk of side effects.
"We realized we needed to deliver this drug selectively to the liver because if it goes to other places, it could cause complications,"Thayumanavan and colleagues used mouse models to confirm that they could direct their carefully developed nanogel carrier with negatively charged surfaces specifically to cells in the liver, called hepatocytes.
"We came up with a very simple approach, using our unique invention – nanogels that we can direct selectively to different targets," ThayumanavanA thyromimetic called axitirome was packaged up into anionic nanogels and administered to obese and control mice daily for five weeks via abdominal injection. The obese mice had been fed a diet high in fat, sugar, and cholesterol for 24 weeks leading up to the treatment.
"We found that we are activating the reverse cholesterol transport pathway, which lowers cholesterol," Thayumanavan"We believe that activation of fat oxidation and an increase in metabolic rate are causing the loss in weight, but more work needs to be done to prove that point." After the ANGs get into the hepatocytes, axitirome is released when the environment in the liver cells breaks down the bonds in the nanogel. The drug then binds to a protein that helps regulate the expression of genes.
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