A tiny hand crafted out of DNA has jointed fingers that can be used to grab small objects like gold nanoparticles or viruses
In another test, they took the fingers and added extra bits of DNA that bind to the spike protein of the SARS-CoV-2 virus. The nanohands could then “grab” viruses and those that had been grabbed were unable to infect cells growing in a culture.Sign up to newsletter
Wang and his colleagues also engineered nanohands to fluoresce when they bound to a specific virus, which could help detect such infectious agents. They are now exploring whether the devices could be used to get drugs into cells, says Wang. One advantage of the nanohands for such applications is that normal DNA is broken down rapidly by enzymes in the blood, but DNA origami structures are more stable. They can also be made to last longer by using ultraviolet light to create extra bonds between the strands or by coating them in certain polymers, says Wang.
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