New research presents a significant discovery: small extracellular vesicles (sEVs) from the blood of young mice possess the capacity to dramatically extend lifespan, rejuvenate whole-body physiology and reverse age-related degenerative changes in aged mice.
Mouse study finds small extracellular vesicles from young blood extend lifespan and restore physiological functionsNew research presents a significant discovery: small extracellular vesicles from the blood of young mice possess the capacity to dramatically extend lifespan, rejuvenate whole-body physiology and reverse age-related degenerative changes in aged mice. The work is
The efficacy of blood exchange therapy in reversing aging has long been a subject of debate, marked by a lack of definitive and compelling evidence. In this study, weekly injections of young sEVs to 20-month-old male mice resulted in a medianincrease to 1,031 days, a 22.7% extension from the typical 840-day lifespan of C57BL/6J male mice. The longest-living mouse survived for up to 1,266 days, which is equivalent to 120–130 human years.
Young sEVs have emerged as one of the most effective rejuvenating factors for extending lifespan. Caloric restriction therapy can extend the median lifespan to 978 days , while oral intake of metformin and nicotinamide can raise the median lifespan to 889 days and 875 days . In comparison, young sEVs have demonstrated superior longevity extension effects on aged mice.
Given that young sEVs are natural vehicles circulating in the bloodstream without causing toxicity or immunogenicity, the infusion of young sEVs may serve as a versatile tool for combating aging, addressing age-related diseases and improving lifelong health in individuals who have already aged.: Mouse study finds small extracellular vesicles from young blood extend lifespan and restore physiological functions retrieved 16 April 2024 from https://medicalxpress.
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