HIGHLY GIFTED Sara Misir is a young motorsports sensation who at the age of 24...
Whilst racing her way around the globe, next up is Donnington Park on September 17 - 18, Sara also studies architecture in FloridaHIGHLY GIFTED Sara Misir is a young motorsports sensation who at the age of 24 is most certainly living life in the fast lane.
Whilst racing her way around the globe, next up at Donnington Park is September 17 – 18, Sara also studies architecture in Florida.How did your love affair with motorsports begin? My dad gave me a go kart and said let’s just give horseback riding a small break, and I fell in love with go karting. At the same time, I hated it, because I went from a sport where I was a pro into something where I knew nothing, and it was very competitive. It was hard, but I had a passion for the adrenaline, the head-to-head racing, using your mind, it’s more than just how fast the car can go. It is race craft, like a chess match.
One hundred per cent! I have a very diverse background in sports. When I was in high school, I used to play about seven different sports, from football, to volleyball, swimming, tennis, any clubs that there were I would join it. I’ve always wanted to balance both team sports and individual sports. So, I think having that diversity of different types of training, different types of coaches has really allowed me to appreciate the competitiveness and to have a good perspective of it.It’s not easy.
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Mar-A-Lago Search Affidavit: Trump Was Insecurely Storing Most Sensitive Intel At ClubThe heavily redacted document lays out the justification the Department of Justice provided to a judge for permission to search for and seize highly classified documents in an FBI raid of Trump's Florida home.
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Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children - BMC MedicineBackground RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, but knowledge on the induction, decay, and determinants of antibody function is limited, especially among children. Antibodies that promote opsonic phagocytosis and other cellular functions appear to be important contributors to RTS,S immunity. Methods We studied a phase IIb trial of RTS,S/AS02 conducted in young children in malaria-endemic regions of Mozambique. We evaluated the induction of antibodies targeting the circumsporozoite protein (CSP, vaccine antigen) that interact with Fcγ-receptors (FcRγs) and promote phagocytosis (neutrophils, monocytes, THP-1 cells), antibody-dependent respiratory burst (ADRB) by neutrophils, and natural killer (NK) cell activity, as well as the temporal kinetics of responses over 5 years of follow-up (ClinicalTrials.gov registry number NCT00197041). Results RTS,S vaccination induced CSP-specific IgG with FcγRIIa and FcγRIII binding activity and promoted phagocytosis by neutrophils, THP-1 monocytes, and primary human monocytes, neutrophil ADRB activity, and NK cell activation. Responses were highly heterogenous among children, and the magnitude of neutrophil phagocytosis by antibodies was relatively modest, which may reflect modest vaccine efficacy. Induction of functional antibodies was lower among children with higher malaria exposure. Functional antibody magnitude and the functional activity of antibodies largely declined within a year post-vaccination, and decay were highest in the first 6 months, consistent with the decline in vaccine efficacy over that time. Decay rates varied for different antibody parameters and decay was slower for neutrophil phagocytosis. Biostatistical modelling suggested IgG1 and IgG3 contribute in promoting FcγR binding and phagocytosis, and IgG targeting the NANP-repeat and C-terminal r
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The effect of COVID-19 on public confidence in the World Health Organization: a natural experiment among 40 countries - Globalization and HealthBackground At a time when a highly contagious pandemic and global political and economic turmoil are intertwined, worldwide cooperation under the leadership of an international organization has become increasingly important. This study aimed to estimate the effect of COVID-19 on public confidence in the World Health Organization (WHO), which will serve as a reference for other international organizations regarding the maintenance of their credibility in crisis management and ability to play a greater role in global health governance. Methods We obtained individual data from the World Values Survey (WVS). A total of 44,775 participants aged 16 and older from 40 countries in six WHO regions were included in this study. The COVID-19 pandemic was used as a natural experiment. We obtained difference-in-differences (DID) estimates of the pandemic’s effects by exploiting temporal variation in the timing of COVID-19 exposure across participants interviewed from 2017 to 2020 together with the geographical variation in COVID-19 severity at the country level. Public confidence in the WHO was self-reported by the respondents. Results Among the participants, 28,087 (62.73%) reported having confidence in the WHO. The DID estimates showed that the COVID-19 pandemic could significantly decrease the likelihood of people reporting confidence in the WHO after controlling for multiple covariates (adjusted OR 0.54, 95% CI: 0.49–0.61), especially during the global outbreak (0.35, 0.24–0.50). The effect was found in both younger individuals (0.58, 0.51–0.66) and older adults (0.49, 0.38–0.63) and in both males (0.47, 0.40–0.55) and females (0.62, 0.53–0.72), with a vulnerability in males (adjusted P for interaction = 0.008). Conclusion Our findings are relevant regarding the impact of COVID-19 on people’s beliefs about social institutions of global standing, highlighting the need for the WHO and other international organizations to shoulder the responsibility of global development for the
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How are the Yorkshire Wolds not designated an Area of Outstanding Natural Beauty? - Yorkshire Post Letters'I totally agree with the comments of The Yorkshire Post’s Editor, the area is definitely amongst the most tranquil countryside, not in England, but Great Britain and in my opinion matches Scotland and Wales.'
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Five injured after car ploughs into pedestrians in HarrowMedics say they do not believe the injuries are life-threatening or life-changing.
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