Molnupiravir and nirmatrelvir-ritonavir treatments are effective in reducing mortality among high-risk COVID-19 patients HKUniversity COVID19 SARSCoV2 Mortality Molnupiravir NirmatrelvirRitonavir
By Dr. Priyom Bose, Ph.D.Oct 12 2022Reviewed by Benedette Cuffari, M.Sc. Since the beginning of the coronavirus disease 2019 pandemic, scientists have worked relentlessly to understand different aspects of the severe acute respiratory syndrome coronavirus 2 .
Based on these findings, non-severe COVID-19 patients with a high risk of hospitalization were treated with these antiviral agents. The standard treatment duration for both molnupiravir and nirmatrelvir-ritonavir is five days, followed by a second course if required. Data were obtained from the Hospital Authority, which manages all public hospitals and clinics in Hong Kong. The clinical outcomes of mild to moderately infected SARS-CoV-2 patients over 60 years who were prescribed molnupiravir and nirmatrelvir-ritonavir were assessed.
An IPTW-adjusted Cox model revealed that mild to moderately infected COVID-19 patients who were at a high risk of complications were associated with a reduced risk of all-cause mortality when prescribed oral antivirals. This was true for both cohorts.
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