For decades, people with diabetes have relied on finger pricks to withdraw blood or adhesive microneedles to measure and manage their glucose levels.
Mar 19 2024ARC Centre of Excellence for Transformative Meta-Optical Systems In addition to being painful, these methods can cause itching, inflammation and infection.
Non-invasive glucose sensing has been a target for almost 30 years due to its implications for pain-free monitoring. Optical glucose sensing techniques have been reported; however, they require complex optical instrumentation usually found in laboratories, making them unsuitable for regular patient use.
In a first-of-its-kind research published in Advanced Sensor Research this week, the team has identified four infrared peaks in glucose that allow selective and sensitive identification in aqueous and biological environments. The team is keen to collaborate with academic and industry partners to continue this work and conduct pre-clinical and clinical research, which would open the door to the development of wearable optical glucose sensors.
Until now, there is no consensus on the unique spectroscopic signature of glucose, largely because the O-H bonds targeted in near-infrared spectroscopy for glucose detection are also abundant in water. This similarity makes it challenging to distinguish between glucose and water signals, especially in complex biological fluids and tissues. We optimized spectroscopy setup and analyzed transmittance to identify peaks unique to glucose.
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