Metformin treatment boosts levels of Lac-Phe, an appetite-suppressing metabolite, potentially offering new insights into its mechanism and opening doors for obesity treatments.
By Tarun Sai LomteMar 19 2024Reviewed by Susha Cheriyedath, M.Sc. A recent study published in the journal Nature Metabolism showed that metformin treatment significantly increases blood levels of N-lactoyl phenylalanine , an appetite-suppressing metabolite.
Study: Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans. Image Credit: LuchschenF / Shutterstock Moreover, Lac-Phe levels were 5.7 times higher in obese T2D subjects than in obese non-T2D volunteers. In addition, these increases were also significant compared to prediabetic individuals. Notably, Lac-Phe levels correlated with the concentrations of other N-lactoyl amino acids. Next, the team analyzed the metabolomic data from the TwinsUK cohort.
This enabled analyses of the Lac-Phe trajectories in participants whose metformin and T2D status changed with time. The researchers noted that metformin treatment significantly increased Lac-Phe levels in individuals newly diagnosed with T2D. By contrast, for newly diagnosed diabetic individuals without metformin therapy, there were no significant changes in Lac-Phe levels.
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