A study conducted in Norway and published in BMCMedicine finds that maternal cholesterol and apolipoprotein A1 levels are more strongly associated with offspring body weight during childhood than paternal levels, supporting a direct intrauterine effect.
]. A strong association between maternal cholesterol level and offspring growth and no or a much weaker association between paternal cholesterol level and offspring growth may indicate that there is a causal maternal intrauterine effect. An important assumption is that maternal and paternal cholesterol levels are affected equally by sources of bias or confounding.
]. The MBRN is a national health registry containing information about all births in Norway. The current study is based on version 11 of the quality-assured data files released for research in September 2018.]. In brief, we excluded parents who had not completed the three questionnaires during pregnancy, who had a multiple pregnancy, miscarriage or stillbirth.
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