Researchers use pathogen genomics of ancient DNA recovered from museum-preserved orangutan teeth to determine the cause of hitherto unexplained deaths of several zoo-housed great apes in the Netherlands in 1965. The study findings provide new insights into how monkeypox virus traveled from its potential origin in Sumatra into the Rotterdam Zoo, where the outbreak occurred.
In a recent research letter published in the journal Emerging Infectious Diseases, researchers use pathogen genomics of ancient DNA recovered from museum-preserved orangutan teeth to determine the cause of hitherto unexplained deaths of several zoo-housed great apes in the Netherlands in 1965.
Shotgun sequencing in tandem with hybridization capture bait sets sensitive to a spectrum of viral genomes revealed that these museum specimens were Sumatran orangutans (Pongo abelii) died due to monkeypox virus (MPXV) infections. The study findings provide new insights into how MPXV traveled from its potential origin in Sumatra into the Rotterdam Zoo, where the outbreak occurred. Furthermore, these findings highlight the unique ability of modern museomic techniques to identify the pathogens responsible for historic epidemiologic events and their dispersal routes to ultimately better prepare for future zoonotic and pandemic events
Monkeypox Virus Ancient DNA Museum Specimens Orangutan Teeth Zoo Outbreak
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