Approximately 80% of patients in intensive care showed clinical improvement in gram-positive bacterial infections after treatment with linezolid.
Overall, 82.2% of patients met the criteria for clinical success; 34 were cured and 267 improved. Clinical success rates for first-line and second-line linezolid therapy were 79.9% and 83.6%, respectively. Failure rates for linezolid were higher for second-line vs. first-line treatment .
A total of 8 patients reported linezolid-related adverse events, and 4 patients discontinued the medication because of them; none reported treatment-related serious adverse events. The low incidence of thrombocytopenia in the current study compared with previous studies may have been related to avoidance of linezolid for at-risk patients as determined by clinicians, and the relatively short duration of linezolid use, the researchers wrote in their discussion.
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