Comparing life-threatening flu and COVID-19 illness in kids umich
]. Differentiating COVID-19 and influenza by symptoms is therefore difficult, and testing is needed to accurately diagnose the causative pathogen in children with acute respiratory illness when both viruses cocirculate.
Our comparative evaluation had notable strengths and limitations. Both the influenza and COVID-19 cohorts were multicenter, geographically diverse, and limited to children admitted to the ICU, allowing comparison of acute severe respiratory illnesses. The sites overlapped , but the COVID-19 cohort had more sites and had waiver of consent, while not all eligible influenza-positive patients consented to PICFLU participation. Furthermore, the inclusion criteria between the studies were different.
In conclusion, despite notable differences in the demographic and clinical characteristics of unvaccinated children with COVID-19 in the pre-Delta and pre-Omicron variant eras compared with children with influenza admitted to the ICU, both viruses were associated with critical illness and the need for life-saving measures.
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