Injecting lidocaine around a breast tumor prior to surgical removal may reduce the risk for metastases and death in patients with early breast cancer, a new prospective randomized study suggests.
Perioperative interventions to prevent metastases have not been well studied, but the use of local anesthesia for that purpose has a scientific basis. Researchers have found that local anesthetics block voltage-gated sodium channels, which can inhibit metastatic pathways, the study authors explained.
All patients received standard postoperative adjuvant treatment, and there were no adverse events associated with lidocaine injection. The effect of lidocaine administration was not significantly different in patients who underwent mastectomy or breast conserving surgery .
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