Large language models generate functional protein sequences across diverse families
We thank B. McCann, C. Gee, E. Procko, K. Trego, L. Varshney, N. Shirish Keskar and S. Savarese for their feedback at various stages of this project. We thank A. Cook, D. Lo and V. Nemali for operational support. Thanks also to the Salesforce Research Computing Infrastructure team and the Google Cloud TPU team for their help with computing resources, in addition to Twist Bioscience for DNA synthesis support. Beamline 8.3.
The Advanced Light Source is a national user facility operated by Lawrence Berkeley National Laboratory on behalf of the US Department of Energy under contract number DE-AC02-05CH11231, Office of Basic Energy Sciences. Icons in one figure were created using BioRender . E.R.G. is supported by NIH F32-GM144982-01. J.S.F. was supported by NIH GM123159, NIH GM145238 and a Sanghvi-Agarwal Innovation Award.
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