A better understanding to the changes in DNA that cause ageing could help slow down the process.
Hungarian scientists has uncovered elements which can destabilise our genetic codes and cause ageing. The research team found a way to control these elements which increased the lifespan of worms by up to a third.
Researchers found that these elements, called 'transposable elements' , destabilise the genetic code and cause ageing when they move around too much. Scientists also identified a specific process, called the 'Piwi-piRNA pathway', that helps to control these TEs. In an experiment, Dr Sturm and Dr Vellai strengthened this pathway in a worm called Caenorhabditis elegans - which incredibly increased the worm's lifespan by up to 30per cent.
The researchers used techniques to 'downregulate' or quieten down the activity of these TEs. When they did this to specific TEs in worms, they showed signs of ageing slower. "This opens the door to a myriad of potential applications in the world of medicine and biology," he excitedly added.
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Scientists Discover DNA Elements Linked to AgeingHungarian scientists have found elements in our DNA that can destabilise genetic codes and cause ageing. However, they have also discovered a way to control these elements, which has increased the lifespan of worms in experiments. The research team hopes that this breakthrough will lead to a better understanding of DNA and potential ways to extend human lifespans.
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