Psychedelics have a history which is probably longer than that of civilisation. They have powerful effects on the brain and their lore is rich in anecdotes about effects on mental health, some for better and some for worse
, a glutamate receptor. Different drugs favour different receptors which is why they have different effects.receptors, inducing a rapid release of serotonin and dopamine. Ketamine and ibogaine, which is extracted from an African shrub, both work onas well as other receptors—including, in the case of ketamine, opioid receptors. The biochemistry of this is also linked to anatomy. Activation of—in which the visual cortex is comparatively rich—seems to be necessary to generate hallucinations.
There are other factors which could limit the uptake of these medicines. Like Spravato they will probably be approved for use only in certified health-care settings and with strict protocols; a patient given a dose of psilocybin, or, requires many hours of supervision. That makes these drugs very unlikely to be the first line of therapy offered to people who roll up at their doctor’s office with depression or anxiety.
There will be potential patients who hope he is right. Some proponents of psychedelics think the mystical experience is integral to the clinical outcome, revealing insights into the psyche that are impossible to obtain any other way. This means they find it hard to bend their minds around the idea that some of the mentally unwell do not want to “change” their consciousness. They just want to get better.
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