Scientists William Kaelin, Peter Ratcliffe and Gregg Semenza win Nobel prize for their work on cellular adaptation to fluctuating oxygen which paved the way for new strategies to fight anaemia and cancer
Nobel Assembly members Patrik Ernfors, Anna Wedell and Randall Johnson sit in front of a screen displaying the winners of the 2019 Nobel Prize in Physiology or Medicine Gregg Semenza, Peter Ratcliffe and William Kaelin after their names were announced during a press conference at the Karolinska Institute in Stockholm, Sweden on October 7, 2019.
"They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function," the jury said. The jury said the trio had identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen, which is central to a large number of diseases.
Ratcliffe is director of clinical research at the Francis Crick Institute in London, and director of the Target Discovery Institute in Oxford.They will receive their prize from King Carl XVI Gustaf at a formal ceremony in Stockholm on December 10, the anniversary of the 1896 death of scientist Alfred Nobel who created the prizes in his last will and testament.
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