And it could change the course of the pandemic. 💉 engineering
across the world, countries may soon face the difficult choice of either imposing strict lockdowns or letting the variant run through the population. Vaccinations are reducing the severity of the disease but are ineffective in halting the spread of the highly transmissible infection.
While recombining the spike protein with a different delivery mechanism is a common strategy used in vaccine design these days, Kohara is confident that his vaccine can not only deliver potent neutralizing antibodies with a single dose, they also induce strong cellular immunity that offers long term protection.
Experiments conducted in mice showed that vaccinated mice maintained high antibody levels for over 20 months or their average lifetime, The Japan Times reported. When two doses were administered, three weeks apart, the neutralizing antibodies increased tenfold, the report said.
Kohara also told the news outlet that the vaccine would offer an added advantage of producing fewer side-effects compared to other vaccines that have been given emergency-use authorizations. The non-pathogenic strain used in the vaccine design is incapable of replicating in mammals and would produce fewer side-effect reactions, Kohara claimed.variants of concern
and found it to be effective. Kohara told the media outlet that he expects it to work against Omicron as well while also stating that the vaccine could be stored at room temperatures making them easy to transport and administer in developing countries with tropical climates. The Tokyo Metropolitan Institute of Medical Science does not have previous experience of commercializing a vaccine and has signed up domestic drugmaker Nobelpharma Co to take it through clinical trials.
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