The experimental drug lecanemab was able to slow down Alzheimer's in a large study. Many researchers think the drug will become the first to help large numbers of patients.
"What we've learned over time is that a very small proportion of individuals will have symptoms," Cohen says,"and when symptoms arise, they are usually transient, mild to moderate, and resolve."
The risk of ARIA appears to be higher in people who are taking blood thinners or who have genes that lead to very high levels of amyloid in the brain, Cohen says. As a result, she says,"there will be patients for whom this is not a good therapy." Alzheimer's itself causes the brain to shrink, a sign that neurons are dying. So Thambisetty expected Alzheimer's drugs to limit shrinkage, rather than accelerate it.of the Mayo Clinic."It's moving in the wrong direction," he said during a panel at the Alzheimer's meeting.
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