Investigating treat-to-target low-density lipoprotein-cholesterol versus high-intensity statins for coronary artery disease yonsei_u Cholesterol Statins Treatment CoronaryArteryDisease
Background CAD management recommendations for selecting statin intensity have advocated two strategies: target-to-treat LDL-C therapy or high-intensity statin administration without predefined LDL targets. Both treatments are used in clinical settings; however, direct comparisons of the strategies concerning safety or effectiveness have yet to be performed.
The prime study endpoint comprised a three-year composite measure of stroke, death, coronary artery revascularization, or myocardial infarction, having a 3.0 percentage point-noninferiority margin. Secondary study endpoints included new-onset diabetes, cardiac failure-associated hospitalizations, pulmonary thromboembolism or deep vein thrombosis, endovascular revascularization for peripheral artery diseases, and aortic intervention or surgery.
Results Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Among 4,400 CAD patients, 99% of individuals completed the follow-up assessments, among whom the mean participant age was 65.0 years, and 28% were women. Individuals receiving TTT treatment had 6,449 individual follow-up years, with high- and moderate-intensity dosing among 54% and 43% of individuals, respectively.
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