The Interdisciplinary Research Institute of Grenoble (CEA-Irig), CEA-Leti, and fellow European and Canadian institutes and researchers have demonstrated the complete vascularization of organoids on a microfluidic chip at speeds and flow rates similar to blood, improving functional maturation and enabling their long-term survival.
International research team achieves first-reported, complete vascularization of organoids on microfluidic chipEndothelial network formation perfusing an organoid trapped in the microfluidic chip. Credit: CEA-Leti
Organoids, which are a 3D assembly of self-organizing cells capable of partially mimicking different physiological characteristics of an organ or tissue, are proving to be highly useful for evaluating the therapeutic efficacy of drugs or new molecules. But they must be vascularized to promote the exchange and transport of nutrients and oxygen, otherwise their maturation and growth are impaired. In vivo, this vascularization is ensured by blood flow.
"Despite rapid advancement in microvascular network systems and organoid technologies, vascularizing organoids-on-chips remains a challenge in tissue engineering. Most existing microfluidic devices poorly reflect the complexity of in vivo flows and require complex technical set-ups." "This work opens new avenues to understand biological mechanisms in much more relevant models of human origin, as well as forand drug development of novel biological therapies," says Xavier Gidrol, CEA-Irig scientist and project supervisor."Organoids have now entered the field of personalized medicine, regenerative medicine, and pharmacological research."
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