Interferon autoantibodies not implicated in long-COVID Autoantibodies LongCOVID Coronavirus Disease COVID PASC Interferon JIDJournal ISID_org HIVMA
By Bhavana KunkalikarMar 6 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in The Journal of Infectious Diseases, researchers assess the proportion of interferon autoantibodies in long-coronavirus disease patients.
Recently, a provocative investigation established a correlation between IFN-ɑ2-specific autoantibodies and pulmonary symptoms during acute COVID-19, as well as two to three months after initial SARS-CoV-2 infection presentation. Samples were obtained between April 21, 2020, and June 29, 2021. These specimens accounted for all cohort members who were enrolled prior to receiving the SARS-CoV-2 vaccination.
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy A total of 272 of the 394-time points that represented 185 unique participants occurred 60 days after the onset of COVID-19 symptoms, which facilitated the detection of long-COVID during the visit.
Autoantibodies specific to IFN-ɑ2 were found in only two of 215 subjects across all time points. Anti-IFN antibodies were identified in the first participant 87 and 115 days after acute COVID-19 infection. In both patients, chronic symptoms were accounted for by long-COVID, despite the fact that both patients had complex hospital courses that could have led to post-hospitalization disorders. In contrast to these two patients with IFN-ɑ2-specific autoantibodies, most of the study group exhibited no levels of detectable anti-IFN antibodies at any time period.
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