Tafenoquine, a prodrug that could fulfill the criteria for a mass eradication campaign.
By Dr. Liji Thomas, MDApr 23 2024Reviewed by Lily Ramsey, LLM With malaria still posing a constant and often deadly threat to billions worldwide, new therapies are urgently required to combat the infection. This is made more difficult by the multiple stages of the parasite’s lifecycle.
While P. falciparum is the most lethal parasite, P. vivax causes the most cases because it has the largest habitat. About 3,300 million people are thus at risk of P. vivax infection globally. They live in the American continents, India, South-East Asia, and the Western Pacific regions. The problem with tafenoquine Tafenoquine is an oral medication taken as a single dose, contrasting with the 14-day regimen required for primaquine. However, it is not suitable for people with glucose-6-phosphate dehydrogenase deficiency, a common enzyme defect, or for those whose G6PD status is unknown.
To address these challenges, research into prodrugs has been conducted to potentially broaden the therapeutic margin, even slightly. Prior studies suggest that these modifications may make tafenoquine safe for use in individuals with G6PD deficiency. The prodrug is designed to remain stable in the bloodstream but is broken down by cathepsin enzymes within the body. Given the absence of non-8-aminoquinoline options for radical cures and the practicality of SC administration in mass eradication efforts, this development could represent a significant advancement.
What did the study show? By modifying the blood-stable linker in the prodrug, the researchers increased the stability of the prodrug fourfold on SC administration.Surprisingly, it targeted the liver, with hepatocyte exposure significantly higher than oral TQ. Simultaneously, it exhibited selectivity, with a significantly lower maximum concentration in the plasma.
Liver Malaria Preclinical Anemia Blood Cell Drugs Metabolites Mouse Model Public Health Research
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Innovative Ayrshire primary school refurbishment project underwaySt Sophia's in Galston will be the first EnerPHit certified school in the UK once the project is complete.
続きを読む »
Innovative tool could safeguard cancer patients from chemotherapy-induced kidney damageUsing patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable study of its kind.
続きを読む »
Innovative breast cancer treatment sequence yields positive resultsResearchers at The University of Texas MD Anderson Cancer Center showed that altering the sequence of breast cancer treatment to administer radiation before mastectomy allowed for concurrent breast reconstruction surgery, which reduced the number of operations required, minimized treatment delays and improved patient satisfaction.
続きを読む »
Emmerdale confirms ‘innovative’ episode for Tom and Belle in abuse storyThings are set to worsen.
続きを読む »
Emmerdale confirms ‘innovative’ episode for Tom and Belle in abuse storyThings are set to worsen.
続きを読む »
Rising dance stars to bring innovative works to The MACThe Dance in Motion programme will see seven choreographers and ensembles at different stages of their careers from across the island present their newest creation
続きを読む »