This article will provide an overview of innovative technologies and materials used to overcome challenges in this area, including drug absorption, drug release, as well as patient compliance, and overall efficacy.
Advancements in drug release technologiesChallenges and considerations in developmentFuture trends in oral drug delivery systems The oral dosage form is the most natural, safe, and convenient route for administering drugs compared to other routes.1
Nanoparticles have shown significant promise in drug delivery, with both organic and inorganic nanoparticles being shown to improve the tolerability of drugs, as well as pharmacological specificity, targeting, and biodegradability.3 Other innovations include microfabricated smart devices, which are comprised of advanced manufacturing approaches such as microfabrication and 3D printing to produce pioneering oral delivery devices. Subsequently, this can lead to precise control over minute devices, as well as discovering novel mechanisms underlying interactions between materials and cells.2
Impact on patient compliance and experience Innovations that aim to increase the absorption of oral dosage forms and control drug release technology may be critical for improving patient compliance and overall treatment experience.3 Additionally, many macromolecular drugs can face denaturation and chemical denaturation in the stomach and intestine; the acidic conditions of the stomach are able to denature most proteins, while in the small intestine, bile salts and proteases can destabilize biologics.2
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