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he composer Ludwig van Beethoven first began to experience hearing loss in his mid-20s. He also suffered from chronic stomach pain and, towards the end of his life, displayed jaundice – the yellow skin associated with liver disease. His health problems have been the subject of much speculation and a team of international scientists have finally gotten some answers: thanks to developments in whole genome sequencing and five strands of his hair.
It took more than a billion dollars and 20 years to sequence the first human genome. Advances in technology have now rapidly driven down the time and cost. A U.K. government agency recently announced a $126 million program to sequence the genomes of up to 200,000 babies for more than 200 genetic diseases. There is a similar project underway in New York City to test 100,000 newborns.
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Beethoven’s Genome Reveals Clues to His Bad Health and Early DeathThe prodigious composer had serious liver problems and a hepatitis infection sometime before he died in 1827.
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Beethoven's death: Whole-genome sequencing from hair reveals Hepatitis BResearchers carry out an advanced genomic analysis of Ludwig von Beethoven’s hair, shedding light on his chronic health problems and cause of death.
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