A third dose of mRNA vaccine may be necessary to protect recipients of organ transplants from COVID19 and produce effective antibody responses against SARSCoV2, suggests a new immunological analysis of kidney transplant recipients. ScienceTM
), though whether one vaccine is more effective than the other in this cohort remains to be evaluated.
This study has several limitations. First, only a limited number of patients were enrolled , the immune response of whom was analyzed at only a single timepoint. Second, the impact of vaccination or infection on the various immune cell subsets was analyzed in peripheral blood instead of the secondary lymphoid organs , where immune responses actually develop.
The COVATRHUS cohort was used to analyze immune mechanisms involved in protection against COVID-19. Twenty-nine patients, naive for SARS-CoV-2 infection, were prospectively recruited from the cohort of kidney transplant recipients of the University Hospital of Strasbourg. According to the recommendations of the French health authority, they received two doses of mRNA-1273 SARS-CoV-2 vaccine.
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