Edits to one bird gene can’t completely stop infections, however
A chicken that had its genes edited to make it resistant to influenza virus goes beak-to-beak with an unedited hen.For 3 decades, Helen Sang has tinkered with the genomes of chickens to try to make the birds resistant to the flu viruses that periodically devastate flocks and raise fears of a human pandemic.
An analysis of the viruses that grew in the modified birds revealed something more disturbing, however: mutations in their polymerase genes. The mutations allowed the enzyme to still get some help from the edited ANP32A protein and also from ANP32B and a third member of the same family, ANP32E, which like ANP32B typically plays no role in influenza replication.
The answer, other researchers say, is more CRISPRing. “Additional genome editing of the ANP family could eliminate the risk of virus escape and adaptation,” says Jae Yong Han, aat Seoul National University. The U.K. team agrees. “The major message of our paper is to use multiple edits,” Barclay says.
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