Immunity wanes against the Omicron variant of the coronavirus with both the Moderna and Pfizer vaccines, but not as much as it wanes after a natural infection, researchers report
A Pfizer Covid-19 vaccine is prepared for administration at a vaccination clinic on September 22, in Los Angeles.
Although the tests were done in lab dishes, the researchers said the experiment replicates real life conditions because they used live virus. They looked for what are known as neutralizing antibodies: immune system structures that can stick to the virus and stop it from infecting cells. “Across all 85 samples, the reduction in neutralization for Omicron was greater than 14.5 fold,” compared with the Beta variant and the original strain, they wrote.
They found no evidence that the Moderna vaccine provides stronger protection than Pfizer’s. The blood of people who got two doses of Pfizer/BioNTech’s vaccine produced antibody neutralization levels that were 23-fold lower against Omicron than against the original strain of the virus, and antibody levels from people who got Moderna’s vaccine were 42 times lower. For people who got booster doses, neutralization activity was 7.5 times lower for the Pfizer/BioNTech vaccine and 16.
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