Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments.
Mar 25 2024Medical University of Vienna Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments. By analyzing draining mesenteric lymph nodes of affected small intestinal segments of patients who had required surgery, a research team led by Lukas Unger from MedUni Vienna identified immune responses that improve our understanding of the disease.
Recent studies had investigated immune responses in mesenteric lymph nodes in models of ulcerative colitis, another chronic inflammatory bowel disease that exclusively affects the large intestine. The insufficient data available to date on Crohn's disease, which often manifests itself in the last section of the small intestine but spares the large intestine, forms the background to the research carried out by Lukas Unger and his team from MedUni Vienna's Department of General Surgery.
B-cell reactions investigated The scientists discovered the answer by comparing lymph nodes from inflamed and non-inflamed segments of the patient's small intestine: This showed that a certain type of immune cell mature in sections affected by Crohn's disease in a quantity and in a way that is not detectable in the patients' healthy intestinal segments.
Investigating precise mechanisms in future research The results form the basis for further research, particularly into the exact mechanisms and the question of how these altered B-cell responses in Crohn's disease patients influence the clinical course after surgery. In addition, new therapeutic strategies could be developed based on the findings.
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