Withdrawn scientific papers have sparked controversy over a drug once viewed as a possible treatment for covid-19
as a miracle cure for covid-19, an antimalarial drug called hydroxychloroquine has rarely been out of the headlines since the start of the pandemic. It was hoped it might find a new use as a therapy in patients who are unwell with the novel coronavirus. But in recent weeks a scientific picture has emerged of a treatment that does not appear to be helping patients at all, and might even be causing harm.
Whether it helps seems clear now: it doesn’t. When it comes to the harm, though, it turns out that the scientific literature may be misleading. On June 4th the, a respected medical journal, retracted a high-profile paper published only a month previously. This had suggested that hydroxychloroquine and its analogue, chloroquine, actually increased the death rate in hospitals when taken by those with covid-19. This led the World Health Organisation to halt its trials of the drug.
Towards the end of May, however, scientists started to question the reliability of the data that had been used. Thehad retracted a separate paper looking at blood pressure medicines in covid-19 which relied on data from the same firm, Surgisphere, that provided the data set for thepaper that 671 hospitals on six continents had provided data. The data set had been said to include almost 100,000 detailed patient records.
Many are wondering, more broadly, what could go so badly wrong as to lead to two retractions of papers at well-known medical journals. There are calls for theOne irony of the affair is that concerns about the rush to publish science during the pandemic had been focused on preprints. These are papers posted online without independent scrutiny. Yet it is two peer-reviewed journals of repute that have found themselves in difficulty.
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