Human gingival epithelial cells become damaged by cannabis smoke condensate universitelaval Cannabis CannabisSmokeCondensate CellDamage
By Dr. Priyom Bose, Ph.D.Jul 5 2022Reviewed by Aimee Molineux Scientists stated that various toxic materials enter the body through the oral cavity. These toxic substances significantly affect different structures of the body, such as the oral mucosa.
Prior studies have indicated that tobacco and cannabis smoke consists of different organic and inorganic chemical compounds that adversely affect cannabis smokers. Cannabis sativa is a common cannabis plant that contains 60 different phytocannabinoids, including cannabinol, cannabigerol, cannabidiol, cannabichromene, and tetrahydrocannabinol.
A new study In a new study published in the Archives of Oral Biology, scientists evaluated the effect of cannabis smoke condensate on the gingival epithelial cells. They determined the effect of CSC on cell shape, adhesion and viability, at intervals of 30 minutes, 60 minutes, 2 hours, and 24 hours, through microscopic observations and lactate dehydrogenase activity assays.
Previous studies reported that DNA gets damaged due to excessive oxidative stress, which sometimes leads to cell apoptosis. In the current study, researchers reported that CSC initiates oxidative stress in the cells, due to the detection of a higher number of reactive oxygen species -positive gingival epithelial cells, compared to the control cells. An increased level of ROS enhances the risk of cell death through apoptosis and autophagy, via simulation of different apoptotic genes.
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