Multiple factors play a role in complex diseases like COVID, and knowing what they are is important for predicting how different people will be affected.
This is where, instead of directly measuring something that you think has an effect on a disease and then seeing if levels of it correlate with disease severity, you instead look at variation in the genes that influence that substance's levels, and examine how this affects disease outcomes.
Genes, on the other hand, don't change during someone's lifetime. They therefore allow you to more reliably identify people with high and low levels of the substances you're interested in, and so make more robust estimates of how something like a blood protein affects a disease like COVID.
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