Researchers investigate the association between maternal oxidative stress during pregnancy and early childhood mental disorders.
By Dr. Priyom Bose, Ph.D.Oct 19 2023Reviewed by Benedette Cuffari, M.Sc. A recent Molecular Psychiatry study investigates the association between maternal oxidative stress during pregnancy and early childhood mental disorders.
Childhood EBP can be classified as internalizing or externalizing EBP. Internalizing EBP is associated with anxiety, depression, and somatic complaints, whereas externalizing EBP includes aggression, impulsivity, inattention, hyperactivity, and opposition. Prenatal, perinatal, and postnatal exposure to differential environmental conditions like tobacco smoke and prescription medications impacts fetal programming, early brain development, and long-term neuropsychiatric outcomes.
Oxidative RNA damage is assessed by estimating 8-hydroxyguanine . Due to higher detectable concentration, 8-OHGua is a more suitable biomarker of OS. Clinical data and biospecimens were collected at birth and four weeks, three, six, nine, 12, and 18 months, as well as two and four years of age. Maternal urine samples were collected at the 36-week pregnancy appointment and analyzed to detect OS biomarkers using liquid chromatography-mass spectrometry .
Although a positive association between the oxidative RNA damage biomarker 8-OHGua and EBP in children was observed, this type of association was not observed with oxidative DNA damage biomarker 8-OHdG.
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