Bacteria live in nearly every habitat on Earth including within soil, water, acidic hot springs and even within our own guts.
Once everything is in place, the cell splits down the middle to make two identical daughter cells.
Now an affiliate faculty member in the University of Michigan Medical School Department of Biological Chemistry and assistant professor in the University of Michigan Department of Molecular, Cellular and Developmental Biology, Vecchiarelli along with a team of researchers conducted a study to better understand organization and movement coordination within a bacterial cell.ship cellular cargo by"surfing" along proteins called ParA/MinD ATPases.
"A lot of the models that we use to understand how bacteria work suggested that there wasn't really any intricate organization for all of these cargos," said Vecchiarelli. "We found over a third of all sequenced bacteria do encode for multiple positioning systems for multiple disparate cargos in the same cell. E. coli is an exception to the norm," Vecchiarelli said.
"We find that there is a lot of crosstalk, interdependencies, and coordination among these organizing processes," Vecchiarelli said."That's why the systems biology approach is so important."Each positioning system is made of an ATPase and its adapter protein, or surfboard, which connects to the cargo. This offers an opportunity to develop a synthetic biology tool allowing researchers to position any cargo they choose by connecting to the adapter.
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