A meta-analysis using the Burden of Proof function identified modest evidence supporting a protective role of vegetable consumption and ischemicheartdisease, stroke and esophageal cancer, but not type 2 diabetes. IHME_UW
, we implemented the Fisher information matrix to the heterogeneity parameter, which corrects potential underestimation of between-study heterogeneity for data-sparse situations. In such cases, the between-study heterogeneity parameter estimate may be zero, simply from lack of data. The Fisher information matrix uses a quantile of gamma, which is sensitive to the number of studies, study design and reported uncertainty.
Significant results for Egger’s regression are flagged as indicating a potential risk for publication and/or reporting biasThe TMREL is the level of exposure that, within the range of values that are theoretically possible at the population level, will minimize the risk of all outcomes associated with that risk combined.
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