According to the researchers, blood vessel cells are a key regulator of brown fat and energy metabolism. Insulin resistance, a significant risk factor for diabetes, develops when the body's cells do not react to insulin and are unable to use the glucose (sugar) in the bloodstream. The condition has
The researchers discovered a new pathway in which endothelial cells drive the body’s metabolism.
Joslin Diabetes Center scientists describe a series of studies designed to investigate the link between insulin, fats, and the vascular system in a paper published in. The group, led by Dr. George King, chief scientific officer and director of research at Joslin, discovered a brand-new method by which the body’s metabolism is controlled by endothelial cells, which line blood vessels.
The team’s further investigation revealed that insulin signals endothelial cells in the blood vessels to produce, which in turn triggers the production of brown fat cells. In the context of insulin resistance, endothelial cells produced less nitrous oxide – a decrease known to raise cardiovascular risk – leading to a drop in brown fat production.
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