A multi-omics workflow of gut microbiome metagenomics, metatranscriptomics & metabolomics, identified microbial pathways responsible for the degradation of 5-ASA in the gut of patients w/ InflammatoryBowelDisease. chuttenh HarvardChanSPH
, but confounding by 5-ASA use was not explored. Given the role of anaerobic gut bacteria in metabolism of NA, it is conceivable that gut bacteria promoted by 5-ASA – or 5-ASA itself – shunts NA towards the glycine conjugation pathway without profound impact on amidation. This phenomenon was not seen in initiators of steroids or biological drugs in the cohort; NUA levels were undetectable in non-5-ASA users. N = 283 independent biological samples.
A) Phylogenetic analysis shows the taxonomic contributions to the MTX and MGX data in the IBDMDB. Also shown are bacteria previously found to acetylate 5-ASA, all of which belong to the Proteobacteria phylum. Notably, only six of these had detectable MGX and MTX levels in the HMP2, which are labeled and listed. B) The abundance of Proteobacteria is low across the vast majority of participants, relative to Firmicutes and Bacteroidetes species.
We took three-pronged approach to identifying 5-ASA metabolizing enzymes; each part was independent of the other. In Part 1, we used two arylamine N-acetyltransferase sequences from
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