Global case series uncovers Mpox resurgence among previously infected or fully vaccinated individuals

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Global case series uncovers Mpox resurgence among previously infected or fully vaccinated individuals
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Researchers elucidated monkeypox's (mpox) epidemiological and clinical features.

By Vijay Kumar MalesuSep 8 2023Reviewed by Lily Ramsey, LLM In a recent study published in The Lancet Infectious Diseases, researchers elucidated monkeypox's epidemiological and clinical features in individuals with a history of infection or vaccination, enhancing the understanding of disease behavior before immunity.

Concerns exist regarding the effectiveness and duration of immunity post-vaccination or following previous infection. Although the PHEIC declaration ended in May 2023, the ongoing transmission of the Clade IIb strain of mpox in humans suggests the potential for future outbreaks. To be considered a confirmed mpox case post-infection, a patient had to display clinical signs and possess a polymerase chain reaction --confirmed infection history, followed by recovery.

Initial findings indicated its efficacy in gauging the disease's severity and tracking its progression. The median age of the participants was 36 years, the majority being White, cis-gendered gay or bisexual men. Interestingly, most reported having multiple male partners and inconsistent condom use, with eight individuals having HIV, all of whom were under effective antiretroviral therapy.

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