DNA and RNA sequencing in large cohorts of patients with RectalCancer treated with NeoadjuvantTherapies identifies biomarkers of response that could inform patient selection for non-operative treatment strategies. DrGarciaAguilar MSKCancerCenter
Differences in first site of metastasis stratified by primary tumor location.
Frequency of RAS/RAF alterations in hypermutated and non-hypermutated tumors stratified by tumor location.Frequency of copy number alterations affecting the p and q arms of chromosome 20 by anatomic location. Frequency of somatic alterations in rectal cancer driver genes for the patients used in our analyses of clinical outcomes, stratified by cohort. Frequency of somatic alterations in oncogenic signaling pathways for the patients used in our analyses of clinical outcomes, stratified by cohort. Left panel shows results from a multivariate analysis of associations between CR and a combination of clinicopathological and genomic features using a logistic regression model.
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