Study found that certain genetic variants in the IL1RN gene significantly reduce COVID-19-related inflammation and mortality in patients, with notable improvements observed in older men carrying specific single-nucleotide variants.
By Hugo Francisco de SouzaMar 19 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in The Journal of Infectious Diseases, researchers investigated the inflammation outcomes of three different Interleukin-1 receptor antagonist gene single-nucleotide variants in acute severe respiratory syndrome coronavirus 2 infection patients.
COVID-19 and the dangers of CRS The coronavirus disease 2019 represents one of the worst pandemics in human history, responsible for almost 7 million deaths worldwide and leaving hundreds of millions of survivors with long-lasting clinical symptoms. In severe cases, the acute respiratory syndrome coronavirus 2 may result in multiorgan failure, acute respiratory distress syndrome , and even death in 10-20% of affected patients.
About the study Previous research by the current group identified the associations of IL1RN genetic variants with osteoarthritis and rheumatoid arthritis outcomes. It revealed that three SNVs improved disease outcomes via hyperinflammation reduction mechanisms. The present study aims to investigate if the same genetic variants could improve COVID-19 outcomes due to the central role of hyperinflammation in severe COVID-19 pathology.
“Plasma cytokines IL-1β, IL-2, and IL-6 were determined by a test developed by ARUP Laboratories and approved by the New York State Department of Health.” “IL1RN rs419598, rs315952, and rs9005 genotype data were available for all patients. Biomarkers noted in the clinical electronic hospital record for IL-1β, IL-2, and IL-6 were available for 642, 645, and 1229 subjects, respectively, whereas other plasma inflammatory markers were available for more than 2000 subjects.”
“RS-associated inflammatory biomarkers were elevated in both patients who survived and died; however, deceased patients had significantly higher levels of IL-6, CRP, procalcitonin, ferritin, and D-dimer, as well as reduced levels of complement components C3 and C4.”
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