What would you do if you believed you had a serious health issue, but the best way to find out for sure might kill you? Researchers at Stanford are focused on developing a food allergy test that’s not only safer, but also more reliable than today’s tests.
"The test is very accurate, but it's also potentially unsafe and even fatal in rare cases," Tang says."That's led to many sham tests advertised online that claim to use hair samples for food tests, but those are inaccurate and potentially dangerous since they may give someone a false sense of confidence about a food they should avoid.
"Unfortunately, both of those are not that accurate and have high false-positive rates," Tang says."The best method is the oral food challenge, which many patients are afraid to do, not surprisingly."In their study, the Stanford researchers focused on a type of white blood cell known as basophils, which releasebasophils, they were able to separate basophils from the blood with a magnetic field in just 10 minutes.
Once isolated, the basophils are exposed to potential allergens. If they react, that’s a sign of an allergy."For true basophil activation, you need the blood to be fresh, which is challenging when you have to send it to a lab," Tang says."Being able to do this kind of test within a clinic or an in-house lab would be a big step forward."While this represents a breakthrough in basophil activation testing, more research is needed to fully develop the system for clinical use.
That said, the results give hope to those with food allergies that tomorrow’s gold-standard test will require only a blood sample without an emergency team standing by.Lab on a Chip : “Exponential magnetophoretic gradient for the direct isolation of basophils from whole blood in a microfluidic system.”
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