Two new studies suggest flu and pneumonia vaccines may provide some protection against Alzheimer's. One study found that people who got at least one flu shot had a 17% reduction in risk—and those with regular vaccinations had their risk drop another 13%.
The first study came from a team at the University of Texas that combed through millions of medical records in a national database. The goal was to find factors that affected a person's risk of getting certain diseases, including Alzheimer's.
"And one of the things that came back was flu shots," says Albert Amran, a medical student of the McGovern Medical School at the University of Texas Health Science Center in Houston and an author of the study. That seemed odd. So Amran and a team of researchers took a closer look at the medical records of about 9,000 people who were at least 60 years old. Some had received a seasonal flu shot. Some hadn't.
"We [tried] to make sure that both groups had an equal amount of, say, smoking status, obesity, diabetes, cardiovascular disease," Amran says. Those are known risk factors for Alzheimer's. The team also looked at factors like education and income, and indicators like the number of prescriptions a person had received, to make sure that people who got vaccines weren't just healthier overall. They weren't.
"To have these guys come out and say, well it looks like getting the vaccine is associated with less [Alzheimer's] was totally the opposite of what any of us thought," Schulz says.vaccines tend to cause inflammation when they stimulate the immune system. And in Alzheimer's disease, he says, inflammation is part of the problem.
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