Short-lived neural connections in the mouse brain help prime sensory circuits, forever affecting the mouse's sense of touch. Neuroscientists have discovered that a receptor protein named mGluR1 helps regulate the timing of these temporary connections.
Short-lived neural connections in the mouse brain help prime sensory circuits, forever affecting the mouse's sense of touch. Neuroscientists have discovered that a receptor protein named mGluR1 helps regulate the timing of these temporary connections. Their findings may help reveal the origins of various neurodevelopmental disorders and new ways of treating them.
In a new study, Pouchelon and her team zero in on a process known as pruning. This is when the brain removes unnecessary connections between neurons. The pruning of long-lasting connections is relatively well-known. Pouchelon's team focuses on special early connections that get cut to make way for long-lasting circuits in the mature brain. Though temporary, these early connections may play a critical role in shaping developing brain circuits.
Pouchelon's team hopes their discovery may serve as a guide for designing future therapeutics to treat brain dysfunction early."The brain is a wonderful machine whose job is to adapt," says Dimitri Dumontier, the postdoc in Pouchelon's lab who co-led this study."So, when you study neurodevelopmental disorders in adults or even teenagers, it is difficult to identify which mechanisms are causing the symptoms.
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